correlation of early and late ejection fractions with ccl5 and ccl18 levels in acute anterior myocardial infarction

background: acute myocardial infarction (ami) is the leading cause of disability and death in iran and many other countries. objective: to investigate the prognostic value of ccl5 and ccl18 in patients with acute myocardial ischemia. methods: in this cohort study we recruited and followed 50 patients with acute anterior myocardial infarction (aami) for developing cardiovascular accidents in a 6-month period. ccl5 and ccl18 levels were measured on admission, at day 5 and at day 180 posthospitalization. results: ccl18 and ccl5 levels at day 180 were higher in patients with late (day 180) and early (day 5) lvef less than 35% compared to those with higher lvef (p=0.05 and p=0.042, respectively). there was a negative correlation between early and late lvef and regional wall motion abnormalities (p=0.001 and p=0.002, respectively). there was also a trend of negative correlation between ccl18 levels at day 5 and lvef levels at day 180 post-hospitalization (p=0.06). conclusion: ccl18 has a correlation with cardiac function in patients with aami and it might be considered as an indicator of poor lvef in patients with aami.